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GSO ISO/TS 13329:2025
GSO - Cover page
Gulf Foreword
ISO - Cover page
Foreword
Introduction
1 Scope
2 Normative references
3 Terms and definitions
4 SDS preparation
 4.1 General
 4.2 Content and general layout of an SDS
  4.2.1 Chemical product and company identification
  4.2.2 Hazard identification
  4.2.3 Composition of ingredients and related information
  4.2.4 First-aid measures
  4.2.5 Fire-fighting measures
  4.2.6 Accidental release measures
  4.2.7 Handling and storage
  4.2.8 Exposure controls and personal protection
  4.2.9 Physical and chemical properties
  4.2.10 Stability and reactivity
  4.2.11 Toxicological information
  4.2.12 Ecological information
  4.2.13 Disposal considerations
  4.2.14 Transportation information
  4.2.15 Regulatory information
  4.2.16 Other information
5 Cut-off values and concentration limits
Annex A (informative) Example measurement methods and standards (ISO/TR 13014)
 Bibliography
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Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
GSO ISO/TS 13329:2025Gulf Standard
GSO ISO/TS 13329:2025
ISO/TS 13329:2024
مواصفة قياسية خليجية
المواد النانونية - تجهيز نشرة بيانات سلامة المواد (MSDS)
Gulf Standard
Nanomaterials — Preparation of safety data sheets (SDS)
ICS:
07.120 ; 13.100

هذه الوثيقة محمية بالقانون
COPYRIGHT PROTECTED DOCUMENT
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All rights reserved to GCC Standardization Organization (GSO). Unless otherwise specified, no part of this publication may be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on the internet or an intranet, without prior written permission. Permission can be requested from either GSO at the address below or GSO's member body in the country of the requester.
Outreach Dept, Knowledge Management Section
GCC Standardization Organization (GSO)
P.O.Box: 85245 Riyadh 12511
Kingdom of Saudi Arabia
إدارة التواصل، قسم إدارة المعرفة
هيئة التقييس لدول مجلس التعاون لدول الخليج العربية (GSO)
ص. ب: 85245 الرياض 12511
المملكة العربية السعودية
Tel: +966115208000 :هاتف
Fax: +966115208010 :فاكس
E-Mail: csc@gso.org.sa :بريد إلكتروني
Website: www.gso.org.sa :موقع ويب
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Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
GSO ISO/TS 13329:2025Gulf Standard

Gulf Foreword

GCC Standardization Organization (GSO) is a regional organization which consists of the national standardization bodies of GCC member states. One of GSO main functions is to issue gulf standards and technical regulations through specialized technical committees.
GSO Technical Council in its meeting number (60) held on 23/10/1446 H, which corresponds to 22/04/2025, has approved Gulf Standard GSO ISO/TS 13329:2025 titled "Nanomaterials — Preparation of safety data sheets (SDS)" in English language which was studied and adopted from International Organization for Standardization Standard ISO/TS 13329:2024 without any technical modifications through the technical program of GSO Technical Committee for Chemical and Textile Products (TC01) in UNITED ARAB EMIRATES schedule .
تقديم خليجي
هيئة التقييس لدول مجلس التعاون لدول الخليج العربية هيئة إقليمية تضم في عضويتها أجهزة التقييس الوطنية في الدول الأعضاء ، ومن مهام الهيئة إعداد المواصفات القياسية واللوائح الفنية الخليجية بواسطة لجان فنية متخصصة.
قرر المجلس الفني لهيئة التقييس لدول مجلس التعاون لدول الخليج العربية في الاجتماع الـ (60) بتاريخ 1446/10/23 هـ ،الموافق 2025/04/22م اعتماد المواصفة القياسية الخليجية رقم GSO ISO/TS 13329:2025 وعنوانها "المواد النانونية - تجهيز نشرة بيانات سلامة المواد (MSDS)" باللغة الانجليزية التي تم دراستها وتبنيها عن المنظمة الدولية للتقييس رقم ISO/TS 13329:2024 بدون إدخال تعديلات فنية عليها ضمن برنامج عمل اللجنة الفنية الخليجية للمواصفات الكيميائية والغزل والنسيج (TC01) المدرجة في خطة الإمارات العربية المتحدة .
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Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
GSO ISO/TS 13329:2025Gulf Standard

Technical

Specification

ISO 13329
Nanomaterials — Preparation of safety data sheets (SDS)
Nanomatériaux — Préparation des fiches de données de sécurité (FDS)
Reference number
ISO/TS 13329:2024(en)
Second edition
2024-09
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Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
GSO ISO/TS 13329:2025Gulf Standard
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Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
GSO ISO/TS 13329:2025Gulf Standard
ContentsPage

Foreword

ISO (the International Organization for Standardization) is a worldwide federation of national standards bodies (ISO member bodies). The work of preparing International Standards is normally carried out through ISO technical committees. Each member body interested in a subject for which a technical committee has been established has the right to be represented on that committee. International organizations, governmental and non-governmental, in liaison with ISO, also take part in the work. ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters of electrotechnical standardization.
The procedures used to develop this document and those intended for its further maintenance are described in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the different types of ISO document should be noted. This document was drafted in accordance with the editorial rules of the ISO/IEC Directives, Part 2 (see www.iso.org/directives).
ISO draws attention to the possibility that the implementation of this document may involve the use of (a) patent(s). ISO takes no position concerning the evidence, validity or applicability of any claimed patent rights in respect thereof. As of the date of publication of this document, ISO had not received notice of (a) patent(s) which may be required to implement this document. However, implementers are cautioned that this may not represent the latest information, which may be obtained from the patent database available at www.iso.org/patents. ISO shall not be held responsible for identifying any or all such patent rights.
Any trade name used in this document is information given for the convenience of users and does not constitute an endorsement.
For an explanation of the voluntary nature of standards, the meaning of ISO specific terms and expressions related to conformity assessment, as well as information about ISO's adherence to the World Trade Organization (WTO) principles in the Technical Barriers to Trade (TBT), see www.iso.org/iso/foreword.html.
This document was prepared by Technical Committee 229 Nanotechnologies.
This second edition cancels and replaces the first edition (ISO/TR 13329:2012), which has been technically revised.
The main change is as follows:
The document has been changed to a Technical Specification.
Any feedback or questions on this document should be directed to the user’s national standards body. A complete listing of these bodies can be found at www.iso.org/members.html.

Introduction

Manufactured nanomaterials are defined as materials that are intentionally produced to have specific properties or a specific composition and which have any external dimension in the nanoscale or internal structure or surface structure in the nanoscale. This document is not a stand-alone document and should be used in conjunction with ISO 11014.[1] This document takes into account the Globally harmonized system of classification and labelling of chemicals (GHS) document on hazard communication, i.e. safety data sheets. The GHS was developed by the United Nations and is being incorporated into the laws of various regions and nations, many of which already have laws that govern the preparation of SDSs.
Currently, there is limited information on the possible hazards of some nanomaterials. In some cases, the degree of risk to workers or others who can be exposed to nanomaterials is partly unknown, as the possible toxicological effects of nanomaterials are not yet well known and exposure is difficult to measure. Most hazard information and communication approaches necessitate preparation of an SDS for hazardous chemicals, including those containing nanomaterials, for use in manufacture, storage, transport or other occupational handling activities. Yet, only a few SDSs contain specific information about nanomaterials or are specific to nanomaterials. Those that exist generally provide insufficient hazard information (see Reference [2]). There is evidence that some nanomaterials can be more hazardous, e.g. more bio-reactive or active, leading to higher toxicity, than the same material in bulk (non-nanoscale) form. Characteristics predictive of potential safety issues or toxicity for manufactured nanomaterials need to be determined and included in the preparation of an SDS. Within the European Union and the UK, the legislation that addresses industrial substances including nanomaterials specifies that hazardous substances and mixtures are accompanied by an SDS when placed on the market.
The most fundamental ethical responsibility faced by manufacturers is to make users aware that nanomaterials have been added to a product and to communicate, in an SDS, the hazards the product can present and the most effective ways to mitigate those hazards, relying on the hierarchy of controls. The hierarchy of controls is a method that is found in nearly every international guidance document on responsible management of nanomaterials. This document considers the precautionary approach in terms of toxicity and other risks associated with nanomaterials. It recommends providing an SDS for nanomaterials and nanomaterial-containing products, regardless of whether or not the material is classified as hazardous, unless there are existing data for the nanomaterial which demonstrates that it is non-hazardous, or if it is not envisaged that they can be released as nano-objects, or their agglomerates and aggregates greater than 100 nm (NOAA), during handling or use.
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Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
GSO ISO/TS 13329:2025Gulf Standard
Technical SpecificationISO/TS 13329:2024(en)
Nanomaterials — Preparation of safety data sheets (SDS)

1Scope

This document provides guidance on the development of content for, and consistency in, the communication of information on safety, health and environmental matters in safety data sheets (SDS) for substances classified as manufactured nanomaterials (and materials or products that contain manufactured nanomaterials). It provides additional information on safety issues associated with manufactured nanomaterials. It provides supplemental guidance to ISO 11014[1] on the preparation of SDSs.

2Normative references

The following documents are referred to in the text in such a way that some or all of their content constitutes requirements of this document. For dated references, only the edition cited applies. For undated references, the latest edition of the referenced document (including any amendments) applies.
ISO 80004-1, Nanotechnologies – Vocabulary — Part 1: Core vocabulary
Globally harmonized system of classification and labelling of chemicals (GHS). United Nations Economic Commission for Europe, Tenth revised edition, 2023

3Terms and definitions

For the purposes of this document, the terms and definitions given in ISO 80004-1, GHS and the following apply.
ISO and IEC maintain terminology databases for use in standardization at the following addresses:
ISO Online browsing platform: available at https://www.iso.org/obp
IEC Electropedia: available at https://www.electropedia.org/
3.1
agglomerate
collection of weakly bound particles or aggregates or mixtures of the two where the resulting external surface area is similar to the sum of the surface areas of the individual components
Note 1 to entry: The forces holding an agglomerate together are weak forces, for example van der Waals forces or simple physical entanglement.
Note 2 to entry: Agglomerates are also termed secondary particles and the original source particles are termed primary particles.
[SOURCE: ISO 80004-1:2023, 3.2.4]
3.2
aggregate
particle comprising strongly bonded or fused particles where the resulting external surface area is significantly smaller than the sum of surface areas of the individual components
Note 1 to entry: The forces holding an aggregate together are strong forces, for example covalent bonds, or those resulting from sintering or complex physical entanglement.
Note 2 to entry: Aggregates are also termed secondary particles and the original source particles are termed primary particles.
[SOURCE: ISO 80004-1:2023, 3.2.5]
3.3
bioaccumulation
process of accumulation of a substance in organisms or parts thereof
[SOURCE: ISO 6107:2021, 3.64]
3.4
biodurability
physicochemical property which depends on dissolution and leaching as well as mechanical breaking and splitting of a material in a physiological solution such as a Gamble solution
Note 1 to entry: The biodurability test is usually performed in vitro.
3.5
biopersistence
ability of a material to persist in a tissue in spite of the tissue’s physiological clearance mechanisms and environmental conditions
[SOURCE: EU R 18748:1999, 1.2, modified — The word "fibre" has been removed and the word "lung" replaced by "tissue".]
3.6
biodegradability
susceptibility of an organic substance to biodegradation
[SOURCE: ISO 6107:2021, 3.68]
3.7
chemical product
substance or mixture
[SOURCE: ISO 11014:2009, 3.1]
3.8
crystallinity
presence of three-dimensional order at the level of molecular dimensions
[SOURCE: ISO 472:2013, 2.240]
3.9
dustiness
propensity of materials to produce airborne dust during handling
Note 1 to entry: Dustiness is not an intrinsic property as it depends on how it is measured.
[SOURCE: EN 1540:2021, 3.1.2.9]
3.10
engineered nanomaterial
nanomaterial designed for a specific purpose or function
[SOURCE: ISO 80004-1:2023, 3.1.8]
3.11
hazard class
nature of the physical, health or environmental hazard as used in GHS
[SOURCE: GHS:2023, Chapter 1.2, modified — Examples removed from definition and "as used in GHS" added.]
3.12
hazard statement
statement assigned to a hazard class and category as used in GHS that describes the nature of the hazards of a hazardous substance or mixture, including, where appropriate, the degree of hazard
[SOURCE: ISO 11014:2009, 3.6, modified — "Hazardous product" replaced with "hazardous substance or mixture" and "as used in GHS" added.]
3.13
incidental nanomaterial
nanomaterial generated as an unintentional by-product of a process
Note 1 to entry: The process includes manufacturing, biotechnological or other processes, including natural processes.
Note 2 to entry: Used as a synonym for “ultrafine particle” in ISO/TR 27628:2007.
[SOURCE: ISO 80004‑1:2023, 3.1.10]
3.14
manufactured nanomaterial
nanomaterial intentionally produced to have selected properties or composition
[SOURCE: ISO 80004‑1:2023, 3.1.9]
3.15
mixture
mixture or solution composed of two or more substances in which they do not react
[SOURCE: GHS:2023, Chapter 1.2]
3.16
nanofibre
nano-object with two similar external dimensions in the nanoscale and the third dimension significantly larger
Note 1 to entry: The largest external dimension is not necessarily in the nanoscale.
[SOURCE: ISO 80004‑1:2023, 3.3.5]
3.17
nanomaterial
material with any external dimension in the nanoscale or having internal structure or surface structure in the nanoscale
Note 1 to entry: This generic term is inclusive of nano-object and nanostructured material.
Note 2 to entry: See also engineered nanomaterial, manufactured nanomaterial and incidental nanomaterial.
Note 3 to entry: The nanoform of a material is a nanomaterial.
[SOURCE: ISO 80004‑1:2023, 3.1.4, modified — Notes to entry have been changed.]
3.18
nano-object
discrete piece of material with one, two or three external dimensions in the nanoscale
[SOURCE: ISO 80004‑1:2023, 3.1.5]
3.19
nanoparticle
nano-object with all three external dimensions in the nanoscale
Note 1 to entry: If the dimensions differ significantly (typically by more than three times), terms such as nanofibre or nanoplate are preferred to the term nanoparticle.
[SOURCE: ISO 80004-1:2023, 3.3.4]
3.20
nanopowder
particulate material only composed of nano-objects
Note 1 to entry: Nanopowder can include agglomerates and/or aggregates in the nanoscale (largest dimension ≤ 100 nm).
[SOURCE: ISO 18451-1:2019, 3.85]
3.21
nanoscale
length range approximately from 1 nm to 100 nm
[SOURCE: ISO 80004‑1:2023, 3.1.1]
3.22
nanostructure
surface or internal feature with one or more dimensions in the nanoscale
Note 1 to entry: A feature includes but is not limited to nano-objects, structures, morphologies or other identifiable areas of nanoscale dimensions. For example, the nanostructure can be a nanopore or a solid feature on an object.
[SOURCE: ISO 80004‑1:2023, 3.1.6]
3.23
nanostructured material
material having internal nanostructure or surface nanostructure
Note 1 to entry: This definition does not exclude the possibility for a nano-object to have internal structure or surface structure. If external dimensions are in the nanoscale, the term nano-object is recommended.
[SOURCE: ISO 80004‑1:2023, 3.1.7]
3.24
particle
minute piece of matter with defined physical boundaries
Note 1 to entry: A physical boundary can also be described as an interface.
Note 2 to entry: This general particle definition applies to nano-objects.
[SOURCE: ISO 26824:2022, 3.1.1, modified — A note to entry has been deleted.]
3.25
primary particle
original source particle of agglomerates or aggregates or mixtures of the two
Note 1 to entry: Constituent particles of agglomerates or aggregates at a certain actual state can be primary particles, but often the constituents are aggregates.
Note 2 to entry: Agglomerates and aggregates are also termed secondary particles.
[SOURCE: ISO 26824:2022, 3.1.4]
3.26
safety data sheet
SDS
document specifying the properties of a substance, its potential hazardous effects for humans and the environment, and the precautions necessary to handle and dispose of the substance safely
[SOURCE: ISO 11139:2018, 3.239]
3.27
substance
chemical elements and their compounds in the natural state or obtained by any production process, including any additive necessary to preserve the stability of the product and any impurities deriving from the process used, but excluding any solvent which can be separated without affecting the stability of the substance or changing its composition
[SOURCE: GHS:2023, Chapter 1.2]
3.28
surface area
area of the external surface of a solid plus the internal surface of its accessible macro-, meso- and micropores
[SOURCE: ISO 9277:2022, 3.10]
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Gulf StandardGSO ISO/TS 13329:2025
GSO ISO/TS 13329:2025Gulf Standard
 Bibliography
[1]
ISO 11014, Safety data sheet for chemical products — Content and order of sections
[2]
Safe Work Australia, 2010, An evaluation of MSDS and labels associated with the use of engineered nanomaterials
[3]
ISO 6107, Water quality — Vocabulary
[4]
EU R 18748, Methods for the determination of the hazard properties for human health of man made mineral fibers (MMMF), Edited by David M. Bernstein and Juan M. Riego Sintes. European commission Joint Research Centre. Institute for Health and Consumer Protection, Unit: Toxicology and Chemical Substances. European Chemicals Bureau, 1999
[5]
ISO 472, Plastics — Vocabulary
[6]
EN 15051:2006, Workplace atmospheres — Measurement of the dustiness of bulk materials — Requirements and reference test methods
[7]
EN 17199-5:2019, Workplace exposure. Measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles – Vortex shaker method
[8]
ISO/TR 27628:2007, Workplace atmospheres — Ultrafine, nanoparticle and nano-structured aerosols — Inhalation exposure characterization and assessment
[9]
ISO/TR 13014, Nanotechnologies — Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment
[10]
SECO [State Secretariat for Economic Affairs, Working conditions/Chemicals and Occupational Health (ABCH)], 2016. Safety data sheet (SDS): Guidelines for synthetic nanomaterials, SECO, Bern
[11]
PRITCHARD D.K. Literature review — explosion hazards associated with nanopowders. Health and Safety Laboratory, 2010
[12]
HOLBROW P., WALL M., SANDERSON E., Bennett Dr., Rattigan W., Bettis R., Gregory D. Fire and explosion properties of nanopowders, Health and Safety Laboratory. 2010
[13]
ISO/TR 12885, Nanotechnologies — Health and safety practices in occupational settings
[14]
ISO/TS 12901-1, Nanotechnologies — Occupational risk management applied to engineered nanomaterials — Part 1: Principles and approaches
[15]
BS 5415-2.2, Supplement No. 1:1986, Safety of electrical motor-operated industrial and commercial cleaning appliances. Particular requirements. Specification for type H industrial vacuum cleaners for dusts hazardous to health
[16]
HAN J.H., LEE E.J., LEE J.H., SO K.P., LEE Y.H., BAE G.N. et al. Monitoring multiwalled carbon nanotube exposure in carbon nanotube research facility. Inhal. Toxicol. 2008, 20 pp. 741–749
[17]
BALAZY A., TOIVOLA M., REPONEN T., PODGORSKI A., ZIMMER A., GRINSHPUN S.A. Manikin-Based Filtration Performance Evaluation of Filtering-Facepiece Respirators Challenged with Nanoparticles. Ann. Occup. Hyg. 2006, 50 (3) pp. 259–269
[18]
ISO/TS 12901-2, Nanotechnologies — Occupational risk management applied to engineered nanomaterials — Part 2: Use of the control banding approach
[19]
AITKEN R.J., CREELY K.S., TRAN C.L. Nanoparticles: An occupational hygiene review. Health and Safety Executive, 2004
[20]
LEE J.H., KWON M., JI J.H., AHN K.H., HAN J.H., YU I.J. Exposure assessment of workplaces manufacturing nanosized TiO2 and silver. Inhal. Toxicol. 2011, 23 (4) pp. 226–236
[21]
OECD Working Party on Manufactured Nanomaterials. https://www.oecd.org/department/0,3355,en_2649_37015404_1_1_1_1_1,00.html
[22]
ISO 18451-1:2019, Pigments, dyestuffs and extenders — Terminology — Part 1: General terms
[23]
ISO 26824:2022, Particle characterization of particulate systems — Vocabulary
[24]
ISO 11139:2018, Sterilization of health care products — Vocabulary of terms used in sterilization and related equipment and process standards
[25]
ISO 9277:2022, Determination of the specific surface area of solids by gas adsorption — BET method
[26]
EN 1540:2021, Workplace exposure - Terminology
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Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
Gulf StandardGSO ISO/TS 13329:2025
GSO ISO/TS 13329:2025Gulf Standard
ICS 07.120; 13.100
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